What does HIGH BIOAVAILABILITY mean and why is it important in a detoxification dietary supplement like ZOI ClearDrops?
Denise Stephens, ZOI CEO (00:00):
I believe our next question is going to take us into that because we want to understand. You're saying some big words here, Dr. Nicholas, and so Carrie, we're coming back to you for the next question,
ZOI Advisor (00:15):
Right? You made a comment there about the bioavailability. What does that exactly mean? And why is that important in a detoxification dietary supplement? Like we have in ClearDrops,
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (00:28):
Right? Okay. Thank you Carrie bioavailability is the proportion of a substance that is absorbed and enters the circulation related to the amount of the substance that was consumed by mouth. Right? Let's think about this. Let's think about intravenous administration. All right. By definition, if a compound is given intravenously gets directly into the circulation. So the bioavailability of this compound is 100%. All right. Now, in contrast, if you consume something that is not absorbed at all, okay. In your gut, then the bioavailability is zero. For instance, let me give you an extreme example again, from pediatrics, let's suppose that the child, swallows and little piece of toy the plastic. Okay. And this little piece of plastic of toy, of course, we make the whole family to freak out about couple of days, and everybody's going to look the poop of the baby, trying to find out if we got the plastic.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (01:54):
All right. Let's suppose that the second day or the next day or two days after we find the plastic in the poop, all right, what is the bioavailability of this particle, zero? I gave this extreme example out of pediatrics to show what is 100% bioavailability? What is zero bioavailability? Okay. Now toxins, heavy metals most of pesticides and herbicides are very water-soluble. And for these reasons, and fortunately they have high bioavailability can easily be absorbed in the gut and pass into circulation for these reasons, the powders of zeolite and suspensions of zeolite that work only in the gut and practically they have zero or extremely low bioavailability. Don't help with these toxins. If there are good powders and good suspensions, probably they can attract and retain some heavy metals that they are in the gut. But this is not the place where these toxins are stored in the human body.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (03:21):
You need the zero light compound that has high bioavailability that can be absorbed, circulate, and reach out in the compartments. That toxins are accumulated. Okay. I hope that now with this explanation of bioavailability becomes more apparent why it is so important. The technology that we have because we have conducted via appropriate study, and it showed that zeolite, the water soluble zeolite fragments that we have in clear drops can be absorbed in this increases the bioavailability. Let's not get it wrong. ClearDrops is not working only systemically after being absorbed ClearDrops worked also in the gut, but all at the same time, systemically, it has the highest possible bioavailability. And this exactly was the issue. And the question that we had when we started this technology, can we make the zeolite crystal number one, water soluble. And for this reason, number two, bio available to help with systemic reversal of accumulation. This question was a starting point for the creation for this technology.
ZOI Advisor (05:00):
And since it's bioavailable, then it can't be a toxin to the human body. Correct.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (05:07):
As you said, can you repeat the question
ZOI Advisor (05:09):
Because it's bioavailable and it's safe for humans to take it, then it can't be considered a toxin. If someone took it, it's safe for everyone.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (05:21):
Absolutely. It hasn't. It has been designated a Clinoptilolite has been designated the grass status that and benign natural crystal.
ZOI Advisor (05:34):
Thank you. Awesome. Great questions, Carrie.