Children are not “small adults”. Will you please elaborate on this most important matter?
Now we’re going to move into the next question that has been posed to the audience. We’ve got a gentleman out of Atlanta, Georgia. We’re going to jump to Malcolm Evans. Malcolm is one of Zoe Global’s highly qualified advisors helping to get the message to the world. So Malcolm take it away.
ZOI Advisor (00:19):
Well, good evening, Dr. Nicholas and I’m pleased to be able to ask you this question directly as the topic of toxicity is becoming more familiar. People are starting to get concerned and parents, and last week during the Q & A session when asked why it is not recommended that children consume ZOI ClearDrops you made quite a profound statement and your statement was children and not small adults. Could you please sort of further elaborate on, on this most important matter and, and your answer?
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (01:11):
Malcolm, thank you so much for going back to this matter what a coincidence. Again, what I said is that in pharmaceutical and medical sciences, children are not considered as quote, small size of adults. We should not consider kids has mini adults. Okay. now very interestingly, a very important paper was published last week. Denise, I don’t know if you can upload the paper that we briefly discussed the last few days.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (01:59):
So, I will go directly to why I said what I said last week. Now this is a paper published. The AAPS journal AAPS is the American association of pharmaceutical scientists. I have the honor and the privilege to be a full member of this leading association. This was published in the journal of the association and the title is age related to changes in pediatric physiology, quantitative analysis of organ weights and blood flows. It implies blood flow to the specific organs. You remember, we said last week that as kids grow up their biochemistry and their physiology changes, it’s not like you have a child of five years old with a certain body weight, and you can compare this child with someone who is, let’s say 100 kilograms, and then you can tell that, okay, as far as the biology of this child, this child is the 5% of the hundred kilograms because they, you know, or the child is 20 kilograms.
So, it is the, the 20% or 30% does not work like that. There’s no such a relation, now Denise, if you can show a little more of the first page this is a very, very important study that was conducted in the United States. It was submitted for publication from the department of pharmaceutical sciences of the state university of New York is a very, very famous school of pharmacy there. Now. I would like to go to the nomograms that we can see in this study practically, they studied the scientists, the development in two distinct lifetime brackets from zero years from the day that the child is born up to two years old and they created nomograms, And then from two years old to 20 years old, and they are present, this is a monumental study and they present these nomograms per organ.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (04:44):
So, here we see the fitting curve or organ weight versus age relationships along with 95% confidence level. And this is for the bracket between two and 20 years old. If you see the middle somewhere we have where it says organ weight in the Y axis. We see the liver of little boys in blue, in the liver, little of girls. Okay. You see kind of a leaner. Okay. how big the liver becomes over time? All right, Denise, can you go to the next it’s per organ. Okay. We can spend hours in analyzing this study. The, one of the components that makes this study monumental is also that the researchers also presented data regarding the blood flow for each specific organ, as percentage of the cardiac output. Okay. I don’t want to tyrannize, you, with all these scientific details, this is difficult.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (06:19):
Even for medical doctors, these kind of studies. So the Denise you can take out the PDF of the study, but I want to highlight and emphasize children are not mini adults and for this reason. Children should not be treated as mini adults. Specific studies with pediatric population must be conducted. If it is to start administering pharmaceutical products or dietary supplements to children. For example, I am taking vitamin D myself every single day. I came from Athens Greece for the first part of my life. I was under the sun and we moved with my wife to Rochester, Minnesota. Now we live in Cleveland. There’s not so much sunshine as it was in the Mediterranean sea. We need to supplement or vitamin D well, we are taking more than 3000 units of vitamin D every single day. Our kids around 10 years old, nine and 11, they don’t need 3000 units per day. They need significantly less.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (07:44):
So, As you know at Metron nutraceuticals and at ZOI Global, we treat our technology very seriously in many aspects of production and production and testing, we treat it as if it goes a pharmaceutical product, and we extend these two recommendations into all the aspects of this technology. I hope that this helps and what the coincidence after we discussed this last week, this study I became aware of this study the last day. So thank you very much again for bringing back this issue. It’s very important issue.
ZOI Advisor (08:26):
Thank you for that expensive answer. It’s very clear. Thank you, sir.
Denise Stephens, ZOI CEO (08:32):
Yes. Thank you so much. Dr. Nicholas, you know, you did a great job of summarizing why? And so with ZOI Global and it Metron Nutraceuticals, we don’t just go with status quo. It’s everything is based in science. And so for that reason, like Malcolm said, thank you for that expansive overview so that we know that when we talk to people, we’re doing the right thing by people. So thank you.
Dr. Nikolaos Tsirikos-Karapanos, PharmD, MD, Cardiothoracic Surgeon (08:57):
First safety first. Yes, absolutely.